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生命科学学院韩管助课题组在逆转录病毒基因选配研究取得重要进展

yabo登录JINQI,JINHUASHENGWUXUEGUOJIZHUMINGQIKANMolecular Biology and Evolution(YINGXIANGYINZI11.062)YI“Frequent retroviral gene co-option during the evolution of vertebrates”WEITIZAIXIANFABIAOLESHENGMINGKEXUEXUEYUANHANGUANZHUJIAOSHOUKETIZUyaboDENGLUNIZHUANLUBINGDUJIYINXUANPEIDEZUIXINYANJIUJINZHAN。

NIZHUANLUBINGDUXUYAOZHENGHEDAOSUZHUJIYINZUZHONGLAIWANCHENGZISHENDEFUZHI。DANGNIZHUANLUBINGDUGANRANSUZHUSHENGZHIXIBAOSHI,ZHENGHEDENIZHUANLUBINGDUBIANHUICONGQINDAICHUANDAOZIDAI,CONGERXINGCHENGNEIYUANXINGNIZHUANLUBINGDU。NEIYUANXINGNIZHUANLUBINGDUGUANGFANCUNZAIYUJIZHUIDONGWUJIYINZHONG。JUEDADUOSHUDENEIYUANXINGNIZHUANLUBINGDUHUIJILEIGEZHONGTUBIAN,CONGERZAISUZHUJIYINZUZHONGSHIHUOHUOPIANDUANHUA。SUZHUYOUSHIHUILIYONGNEIYUANXINGNIZHUANLUBINGDUJIYINLAIXINGSHIZISHENSHENGWUXUEGONGNENG(TU1),ZHEIGEGUOCHENGZAIJINHUASHENGWUXUEZHONGBEICHENGWEIXUANPEI(co-option)。LIRU,YIZHIDUOZHONGNIZHUANLUBINGDUFUZHIDEXIANZHIXINGYINZIFv1YIJICANYUDAOPEITAIFAYUDESyncytinsDOUSHIXUANPEIDENIZHUANLUBINGDUJIYIN。DANMUQIANDUIJIZHUIDONGWUZHONGNIZHUANLUBINGDUJIYINXUANPEISHIJIANSHANGWUXITONGDEYANJIU。

韩管助课教授题组在756种脊椎动物基因组中系统地挖掘了逆转录病毒基因选配事件(图2),共发现177个逆转录病毒选配事件。其中,93个选配事件涉及到逆转录病毒gag基因,gag基因选配事件主要发生在哺乳动物和鸟类中。84个选配事件涉及到逆转录病毒env基因,env基因选配事件主要发生在哺乳动物、鸟类和鱼类中。通过对选配事件发生的时间进行分析,发现选配事件的数目随着时间的推移而增多,仅有少数的选配的逆转录病毒基因在长时间尺度上被维持,这些结果表明逆转录病毒基因选配可以在脊椎动物中频繁的发生和丢失。

yabo登录YIBANRENWEI,CANYUDAOBINGDUYUSUZHUJIANJINHUAJUNBEIJINGSAIDESUZHUJIYINHUISHOUDAOZHENGXUANZE。GAIYANJIUTONGGUOXUANZEYALIFENXIZAIHENDUOXUANPEIDENIZHUANLUBINGDUJIYINZHONGFAXIANLEZHENGXUANZEDEZHENGJU,BIAOMINGZHEIXIEJIYINKENENGCANYUDAOBINGDUYUSUZHUJIANJINHUAJUNBEIJINGSAIZHONG。HAIYOUBUFENXUANPEIDENIZHUANLUBINGDUJIYINDEJINHUAZHUYAOSHOUDAOFUXUANZE,BIAOMINGZHEIXIEJIYINKENENGZHUYAOCANYUDAOFEIKANGBINGDUDESUZHUGONGNENGZHIZHONG。XUANPEIDENIZHUANLUBINGDUJIYINSHOUDAOBUTONGDEXUANZEYALIBIAOMINGZHEIXIEXUANPEIDEJIYINKENENGXINGSHILEDUOZHONGSUZHUXIBAOSHENGWUXUEGONGNENG。ZONGZHI,GAIYANJIUWEIZAIJIZHUIDONGWUJINHUAGUOCHENGZHONGFASHENGDENIZHUANLUBINGDUXUANPEISHIJIANTIGONGLEYIFUQUANJINGTU,DUIQUANMIANLIJIENIZHUANLUBINGDUHEJIZHUIDONGWUJIANHUZUODEJINHUAJUYOUSHIFENZHONGYAODEYIYI。

XIANGGUANYANJIUFABIAOZAIJINHUASHENGWUXUEGUOJIZHUMINGQIKANMolecular Biology and EvolutionSHANG(WENZHANGLIANJIE: ),SHUOSHIYANJIUSHENGWANGJIANHUATONGXUEWEIDIYIZUOZHE,HANGUANZHUJIAOSHOUWEITONGXUNZUOZHE。XIANGGUANYANJIUSHOUDAOGUOJIAZIRANKEXUEJIJIN、JIANGSUSHENGYOUSHIXUEKEJIANSHEXIANGMUDENGDEZHICHI。

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    2020NIAN07YUE16RI 16:03

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