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生科院胡志刚副教授-郭志刚教授课题组揭示DNA修复蛋白调控肿瘤进展新机制

YANJIUBIAOMING,DNAXIUFUMEIYUZHONGLIUDEFASHENGYUZHILIAOMIQIEXIANGGUAN,XIBAONEIDNAXIUFUMEIXIANGYIBASHUANGRENJIAN。YIFANGMIAN,ZAIZHENGCHANGXIBAONEI,DNAXIUFUMEIBANGZHUXIBAODIKANGZIFAHUOYOUDAODEDNASUNSHANG,WEICHIJIYINZUWENDINGXING,FANGZHIJIYINTUBIAN。LINGYIFANGMIAN,ZAIZHONGLIUXIBAONEI,DNAXIUFUMEIBANGZHUZHONGLIUXIBAODIKANGHUALIAOYAOWUDEZUOYONG,DAOZHIHUALIAOSHIXIAO。YINCI,YANJIUDNAXIUFUMEIDEGONGNENGYUDIAOJIEJIZHI,DUIYUZHONGLIUJICHUYANJIUYIJIKAIFAXINYIDAIKANGZHONGLIUYAOWU,JUYOUZHONGYAODELILUNHELINCHUANGYIYI。

ZUIJIN,SHENGKEYUANHUZHIGANG-GUOZHIGANGKETIZUYIDNAJIANJIQIECHUXIUFUTUJING(BER)ZHONGDELIANGGEGUANJIANMEIFEN1HEPolβWEIYANJIUDUIXIANG,SHENRUCHANMINGLEDNAXIUFUDANBAIDIAOKONGZHONGLIUFASHENGDEXINJIZHI,WEIZHONGLIUDEYUFANGHEZHILIAOTIGONGLEXINDEBADIANHEYAOWUKAIFASILU。YANJIUCHENGGUOLIANXUZAI《Oncogene》SHANGFABIAOLIANGPIANLUNWEN。《Oncogene》WEINatureCHUBANJITUANXIAZUIZHIMINGDEZHONGLIUZHUANYEQIKANZHIYI,2020NIANYINGXIANGYINZIWEI7.97。

在第一篇文章中,课题组研究发现一种新的microRNA--MicroRNA-140,可以靶向阻断肿瘤细胞中DNA修复酶FEN1的表达,从而抑制乳腺癌细胞的增殖和克隆形成能力。该microRNA和化疗药物如阿霉素联合使用时,显著地增强了乳腺癌细胞对化疗药物的敏感性。该研究成果以“MicroRNA-140 impedes DNA repair by targeting FEN1 and enhances chemotherapeutic response in breast cancer”为题发表在《Oncogene》(2020)39: 234-247。论文第一作者为生科院硕士生鲁潇,yabo登录郭志刚教授,胡志刚副教授为并列通讯作者。论文链接:

在第二篇文章中,课题组以乳腺癌和肺癌为研究模型,发现Polβ高表达能够有效抑制乳癌细胞的侵染和转移,提示Polβ是个潜在的抗肿瘤药物开发的靶点。研究成果以”DNA polymerase beta modulates cancer progression via enhancing CDH13 expression by promoter demethylation”为题于2020年7月8日在《Oncogene》上在线发表。论文第一作者为生科院博士生王梅娜,yabo登录胡志刚副教授和郭志刚教授为论文并列通讯作者。论文链接:

yabo登录TUZHU: C)GUOBIAODAPolβDEZHONGLIUZUZHIYUZHENGCHANGZUZHIJIEMIANQINGXI(YOU),ERDUIZHAOZUZHONGLIUZUZHIQINRANDAOZHENGCHANGZUZHIZHONGLE(ZUO);D)GUOBIAODADEZHONGLIUXIBAOZAIXIAOSHUZHONGSHENGZHANGDEDAOYIZHI(ZUOYOUDUIBI);E)WEIDDEJIEPOUTU。

HUZHIGANGFUJIAOSHOU: 2007.2-2009.12,JIUDUHANGUODONGYADAXUESHENGMINGKEXUEXUEYUAN,HUOLIXUEBOSHIXUEWEI;2010.1-2013.11MEIGUOSITANFUDAXUEYIXUEYUANBOSHIHOU;2014NIANRUZHINANSHIDASHENGKEYUAN,YUGUOZHIGANGJIAOSHOUZUCHENGKETIZU。MUQIANWEIMEIGUOSHENGLIXUEHUIHUIYUAN、JIANGSUSHENGSHENGLIXUEHUIMISHUZHANG。

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    2020NIAN07YUE10RI 15:42

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