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【学术预告】蛋白质组特异性标记-从定性定量到功能结构组学分析

化行楼226

报告题目: yabo登录蛋白质组特异性标记-从定性定量到功能结构组学分析

报告人: 王方军研究员

报告时间: 2019年12月24日(周二)上午9: 30

地点yabo登录: 化行楼226会议室

邀请单位yabo登录: 化学与材料科学学院

报告人简介:

 

王方军,yabo登录中国科学院大连化学物理研究所研究员,张大煜青年学者,生物分子结构表征新方法研究组组长

yabo登录2005NIANYUZHEJIANGDAXUEHUODEXUESHIXUEWEI,2011NIANYUZHONGKEYUANDALIANHUAWUSUOHUODEBOSHIXUEWEI,SHICONGZOUHANFAYANJIUYUAN;TONGNIANPOGEHUODEDALIANHUAWUSUO“BAIRENJIHUA”ZIZHU;HUO2012NIANZHONGKEYUANYOUXIUBOSHIXUEWEILUNWEN,2013NIANUCAS-SpringerYOUXIUBOSHIXUEWEILUNWEN;2014NIANRUXUANZHONGKEYUANQINGNIANCHUANGXINCUJINHUI。DANRENZHONGGUODANBAIZHIZUXUEZHUANYEWEIYUANHUILISHI,ZHONGGUOFENXICESHIXIEHUIQINGNIANXUESHUWEIYUANHUIWEIYUAN。

依托高效色谱-质谱和先进激光光源,开展生物分子结构和相互作用表征新方法研究,致力于发展整体蛋白质,蛋白质复合物,蛋白质-小分子相互作用分析新方法,并将其应用于功能性蛋白质及其复合物组成和结构分析,小分子抑制剂筛选等方面。发表SCI论文100余篇,主要发表在Angew. Chem. Int. Ed.,ACS Nano,Anal. Chem.,Chem. Commun.,J. Proteome Res.,J. Chromatogr. A,Anal. Chim. Acta等学术期刊;SCI他引2200余次,H-index 30。

报告摘要:

yabo登录DANBAIZHIJIEGOUYUQISHENGWUXUEGONGNENGZHIJIEXIANGGUAN,DANBAIZHIGONGNENGDEDIAOKONGYEZHUYAOYILAIYUQIGOUXIANGHEXIANGHUZUOYONGDEDONGTAIDIAOJIE。DUIDANBAIZHIJIEGOUHEGONGNENGDEYANJIUYIZHISHISHENGMINGKEXUELINGYUDEYANJIUREDIAN,YESHIDANGQIANDANBAIZHIZUXUEYANJIUDEZHONGYAOFAZHANFANGXIANG(Trends Anal. Chem. 2019, 118, 771-778)。yaboDENGLUZAI2016NIANTICHULEHUOXINGDANBAIZHIFUHEWUERJIAJIHUAGONGJIABIAOJICELVE,GENJULAIANSUANCELIANANJIBIAOJIXIAOLVSHIXIANLEDUILAIANSUANFANYINGXINGDEDINGLIANGFENXI,YIJIDUILAIANSUANJINCHENGWEIHUANJINGDEDONGTAIJIANCE(Anal. Chem. 2016, 88, 12060-12065)。GAIFANGFASHIYIZHONGFENXIDANBAIZHIHUZUOJIEMIANHEJIEGOUBIANHUADEZHIPUXINFANGFA,YUCHUANTONGQINGDAOJIAOHUAN、QIANGJIZIYOUJIYANGHUADENGZHIPUFANGFAXIANGBIJUYOUWENDINGXINGHAO、BIAOJIXIAOLVHETEYIXINGGAO、SHUJUCHULIJIANDANDENGYOUDIAN,KEYIYINGYONGYUDANBAI-DANBAI、DANBAI-XIAOFENZIDENGSHENGWUFENZIHUZUOJIEMIANHEJIEGOUDIAOJIEFENXI。yaboDENGLUSHIXIANLEJIYUDINGLIANGLAIANSUANFANYINGXINGBIANHUADEDANBAISHOUTIJIEGOUDIAOJIEJIZHIZHIPUFENXI,DUIXIAOFENZIPEITIRo25-6981,Gavestinel,UBP710HEMODANBAISHOUTINMDARsDEXIANGHUZUOYONGFENZIJIZHIJINXINGLEXITONGYANJIU,ZHENGMINGLEGAIFANGFABUJINKEYIFAXIANXIAOFENZIYUDANBAIZHIDEZHIJIEZUOYONGQUYU,HAIKEYIJIANCEDANBAIZHICHANSHENGLEGOUXIANGBIANHUADEQITAQUYU(Chem. Commun. 2019, 55, 4311-4314)。yaboDENGLULIYONGDINGLIANGLAIANSUANFANYINGXINGFENXIHAISHIXIANLETONGSHIJIANCEXIAOFENZIYIZHIJIDUIAurora AJIMEIDEGOUXIANGYIZHIMOSHIHEYIZHIXIAOLI;SHIXIANLEYIZHIJIDUIDANBAIZHIJIMEISHANGSUOYOULAIANSUANWEIDIANHUAXUEBIAOJIFANYINGHUOXINGYINGXIANGDELIANGHUAFENXI,JIESHILECANYUJIMEIDONGTAIYIZHIDEJUTIDANBAIZHIQUYU(Anal. Chem. 2019, 91, 13222-13229)。

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